Tumor Drug Distribution after Local Drug Delivery by Hyperthermia, In Vivo

Drug delivery and drug targeting: Drug targeting using thermally responsive polymers and local hyperthermia.

We report a new thermal targeting method in which a thermally responsive drug carrier selectively accumulates in a solid tumor that is maintained above physiological temperature by externally applied, focused hyperthermia. We synthesized two thermally responsive polymers that were designed to exhibit a lower critical solution temperature (LCST) transition slightly above physiological temperatur...

Local Drug Delivery

Periodontal diseases are considered infection of the periodontium, because there is bacterial etiology, an immune response, and tissue destruction. Putative pathogens associated with periodontal diseases are susceptible to a variety of antiseptics and antibiotics. Methods employed to convey antimicrobial agents into periodontal pockets have included rinsing, irrigation, systemic administration,...

Local drug delivery in periodontology

Periodontitis describes a group of related inflammatory disease resulting in destruction of the tissues that support the tooth. It results from extension of the inflammatory process initiated in the gingiva to the supporting periodontal tissues. Clinical features of periodontitis include bleeding, pus discharge, halitosis, tooth mobility, functional impairment and ultimately tooth loss. Scaling...

Advances in Targeted Drug Delivery

Advances in Targeted Drug Delivery